Varaico: Literature-Extracted Genetic Variants

Gene:APOE
Variant:p.V287E
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APOE

NM_000041.4:p.V287E

Associated Papers

TREM2-apoE3 interactions and Alzheimer's disease: Molecular and structural insights and effects of TREM2 R47H and apoE4 variants.

Greer RA et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025

Characterization of the N- and C-terminal domain interface of the three main apoE isoforms: A combined quantitative cross-linking mass spectrometry and molecular modeling study.

Mohammadi A et al.

Biochimica Et Biophysica Acta. General Subjects, 2025

Human apolipoprotein E glycosylation and sialylation: from structure to function.

Moon HJ et al.

Frontiers in Molecular Neuroscience, 2024

Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.

Lewkowicz E et al.

Cellular and Molecular Life Sciences : Cmls, 2023

Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.

Lewkowicz E et al.

Biorxiv : the Preprint Server for Biology, 2023

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.

Nemergut M et al.

Molecular Neurodegeneration, 2023

The LDL receptor binding domain of apolipoprotein E directs the relative orientation of its C-terminal segment in reconstituted nascent HDL.

Kothari S et al.

Biochimica Et Biophysica Acta. Biomembranes, 2021

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.

Chen Y et al.

Neuron, 2021

In silico analyses of deleterious missense SNPs of human apolipoprotein E3.

Pires AS et al.

Scientific Reports, 2017

Resonance assignments and secondary structure of apolipoprotein E C-terminal domain in DHPC micelles.

Lo CJ et al.

Biomolecular Nmr Assignments, 2015

The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.

Garai K et al.

Biochemistry, 2014

Concerning the structure of apoE.

Frieden C et al.

Protein Science : a Publication of the Protein Society, 2013

Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Mahley RW et al.

Neuron, 2012

Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization.

Huang RY et al.

Biochemistry, 2011

Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3, and E4.

Gau B et al.

Biochemistry, 2011

Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR.

Garai K et al.

Protein Science : a Publication of the Protein Society, 2010

A monomeric, biologically active, full-length human apolipoprotein E.

Zhang Y et al.

Biochemistry, 2007

A monomeric human apolipoprotein E carboxyl-terminal domain.

Fan D et al.

Biochemistry, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."