Associated Papers
Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release.
Zhao R et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.
Liu H et al.
Brain : a Journal of Neurology, 2025
Generation of Alzheimer's Disease Model Derived from Induced Pluripotent Stem Cells with APP Gene Mutation.
Kim Y et al.
Biomedicines, 2024
Whole-exome sequencing detected a novel APP variant in a Han-Chinese family with Alzheimer's disease.
Zhaoxia W et al.
Molecular Biology Reports, 2023
An Alternative View of Familial Alzheimer's Disease Genetics.
Lardelli M
Journal of Alzheimer's Disease : Jad, 2023
Rare Amyloid Precursor Protein Point Mutations Recapitulate Worldwide Migration and Admixture in Healthy Individuals: Implications for the Study of Neurodegeneration.
Abondio P et al.
International Journal of Molecular Sciences, 2022
Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations.
Liu Y et al.
Frontiers in Aging Neuroscience, 2022
Can Anti-β-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?
Imbimbo BP et al.
Neurology. Genetics, 2021
Amyloid-β1-43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations.
Perrone F et al.
Alzheimer's Research & Therapy, 2020
Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease.
Chávez-Gutiérrez L et al.
Seminars in Cell & Developmental Biology, 2020
The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells.
Guyon A et al.
Plos One, 2020
Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer's disease pathogenesis.
Li NM et al.
Neural Regeneration Research, 2019
Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.
Bi C et al.
Aging and Disease, 2019
Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.
Huang CY et al.
Journal of the Neurological Sciences, 2019
Genetic Markers of Alzheimer's Disease.
Nikolac Perkovic M et al.
Advances in Experimental Medicine and Biology, 2019
The genes associated with early-onset Alzheimer's disease.
Dai MH et al.
Oncotarget, 2018
Untangling Genetic Risk for Alzheimer's Disease.
Pimenova AA et al.
Biological Psychiatry, 2018
Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay.
Law BM et al.
Journal of Alzheimer's Disease : Jad, 2018
BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
Zhang S et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2017
Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease.
Tcw J et al.
Cold Spring Harbor Perspectives in Medicine, 2017
Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A et al.
The Journal of Biological Chemistry, 2016
β-Amyloid pathogenesis: Chemical properties versus cellular levels.
Tiwari MK et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2016
A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences.
Shea YF et al.
Journal of the Formosan Medical Association = Taiwan Yi Zhi, 2016
Genes associated with Alzheimer's disease: an overview and current status.
Giri M et al.
Clinical Interventions in Aging, 2016
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio.
Xu TH et al.
Cell Discovery, 2016
Direct Correlation of Cell Toxicity to Conformational Ensembles of Genetic Aβ Variants.
Somavarapu AK et al.
Acs Chemical Neuroscience, 2015
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes.
Hubin E et al.
Cellular and Molecular Life Sciences : Cmls, 2015
On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.
Sala Frigerio C et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015
Cellular functions of the amyloid precursor protein from development to dementia.
van der Kant R et al.
Developmental Cell, 2015
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease.
Thal DR et al.
Acta Neuropathologica, 2015
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
Maloney JA et al.
The Journal of Biological Chemistry, 2014
Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavage.
Li S et al.
Cell Death & Disease, 2014
Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Kamp JA et al.
Reviews in the Neurosciences, 2014
Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies.
Chen WT et al.
Plos One, 2012
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
Zhou L et al.
Embo Molecular Medicine, 2011
Molecular genetics of Alzheimer's disease: an update.
Brouwers N et al.
Annals of Medicine, 2008