Varaico: Literature-Extracted Genetic Variants

Gene:APP
Variant:p.K51M
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APP

NM_000484.4:p.K51M

Associated Papers

Understanding Tau pathology: Insights from animal models.

Zhang H et al.

Zoological Research, 2025

The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges.

Zheng H et al.

International Journal of Molecular Sciences, 2024

MAPT mutations, tauopathy, and mechanisms of neurodegeneration.

Strang KH et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2019

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.

Maeda S et al.

Embo Reports, 2016

Regulation of alternative splicing of tau exon 10.

Qian W et al.

Neuroscience Bulletin, 2014

The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers.

Benitez BA et al.

Plos Genetics, 2013

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort.

Jin SC et al.

Alzheimer's Research & Therapy, 2012

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families.

Cruchaga C et al.

Plos One, 2012

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