Associated Papers
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice.
Prakasam R et al.
Nature Communications, 2023
Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis.
Ren QN et al.
Hepatology (baltimore, Md.), 2022
Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy.
Gogia N et al.
Frontiers in Molecular Neuroscience, 2022
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Scaramuzzino C et al.
Neuron, 2015
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.
Palazzolo I et al.
Neuron, 2009
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.
Palazzolo I et al.
Human Molecular Genetics, 2007
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