Varaico: Literature-Extracted Genetic Variants

Gene:AR
Variant:p.L702H
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AR

NM_000044.6:p.L702H

Associated Papers

Characterizing Longitudinal Molecular Changes in ctDNA in Patients with Metastatic Castration-resistant Prostate Cancer.

Jani CT et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2026

Outcomes for Patients With SPOP Mutated Castration-Resistant Prostate Cancer (CRPC) Treated With an Androgen Receptor Pathway Inhibitor (ARPI).

Park JJ et al.

Clinical Genitourinary Cancer, 2026

Circulating Tumor DNA as a Biomarker for Precision Medicine in Prostate Cancer: A Systematic Review.

Chanhih N et al.

International Journal of Molecular Sciences, 2025

Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C-CAT Database.

Tsukahara S et al.

Cancer Medicine, 2025

Clinical Context Shapes the Relationship between Genomic Alterations and Response to AR Inhibitors and Chemotherapy in Metastatic Prostate Cancer.

Shah K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025

Clinical implications of AR alterations in advanced prostate cancer: a multi-institutional collaboration.

Zengin ZB et al.

Prostate Cancer and Prostatic Diseases, 2025

Deep targeted sequencing of circulating tumor DNA to inform treatment in patients with metastatic castration-resistant prostate cancer.

Nørgaard M et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2025

An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer.

Bae TH et al.

Cancer Research, 2025

Histopathologic and Molecular Characterization of IDH-Mutant Prostatic Adenocarcinoma.

Samueli B et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025

Comparison of androgen receptor mutation detection between plasma extracellular vesicle DNA and cell-free DNA and its relationship to prostate cancer prognosis.

Ding T et al.

Annals of Medicine, 2024

Structural perspectives on the androgen receptor, the elusive shape-shifter.

Johnson MJ et al.

Steroids, 2024

Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project.

Shiota M et al.

Bjc Reports, 2024

39516321 (PubMed )
Supplement: 44276_2024_49_MOESM4_ESM.xlsx › supplementary_table_2

Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasis.

Sallah S et al.

Plos One, 2024

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity.

Wei Y et al.

Molecular Oncology, 2023

37584393 (PubMed )
Supplement: MOL2-17-2183-s002.xlsx › Table_S6

Clinical implications of AR alterations in advanced prostate cancer: A multi-institutional collaboration.

Dorff T et al.

Research Square, 2023

Circulating Tumor DNA Analysis on Metastatic Prostate Cancer with Disease Progression.

Bang S et al.

Cancers, 2023

37568814 (PubMed )
Supplement: cancers-15-03998-s001.zip › Supplementary_Table_S1_Patient_demographics.xlsx › Sheet1

Androgen receptor mutations modulate activation by 11-oxygenated androgens and glucocorticoids.

Snaterse G et al.

Prostate Cancer and Prostatic Diseases, 2023

Symphony in the crowd: Key genetic alterations in prostate cancer.

Masud N

Cancer Innovation, 2023

A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.

Doamekpor SK et al.

Acta Crystallographica. Section F, Structural Biology Communications, 2023

Genetic profiling of hormone-sensitive and castration-resistant prostate cancers and identification of genetic mutations prone to castration-resistant prostate cancer.

Wang Z et al.

Prostate Cancer and Prostatic Diseases, 2023

Yeast-based evolutionary modeling of androgen receptor mutations and natural selection.

Zhang H et al.

Plos Genetics, 2022

Androgen receptor mutations for precision medicine in prostate cancer.

Shiota M et al.

Endocrine-related Cancer, 2022

Structural and molecular insights into the mechanism of resistance to enzalutamide by the clinical mutants in androgen receptor (AR) in castration-resistant prostate cancer (CRPC) patients.

Khan A et al.

International Journal of Biological Macromolecules, 2022

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.

Herberts C et al.

Nature, 2022

Genomic Profiling of Prostate Cancer: An Updated Review.

Hatano K et al.

The World Journal of Men's Health, 2022

Comprehensive genomic profiling of treatment resistant metastatic castrate sensitive prostate cancer reveals high frequency of potential therapeutic targets.

Kappel C et al.

Clinical Genitourinary Cancer, 2022

Cell-Free DNA Variant Sequencing Using Plasma and AR-V7 Testing of Circulating Tumor Cells in Prostate Cancer Patients.

Lieb V et al.

Cells, 2021

Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies.

Jacob A et al.

Cancers, 2021

Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition.

Annala M et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients.

Lallous N et al.

Cancers, 2021

Plasma tumor gene conversions after one cycle abiraterone acetate for metastatic castration-resistant prostate cancer: a biomarker analysis of a multicenter international trial.

Jayaram A et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2021

Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?

Mayayo-Peralta I et al.

Endocrine-related Cancer, 2021

Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer.

Branch JR et al.

Molecular Cancer Therapeutics, 2021

Genomic Testing in Patients with Metastatic Castration-resistant Prostate Cancer: A Pragmatic Guide for Clinicians.

Merseburger AS et al.

European Urology, 2021

Gene polymorphism-related differences in the outcomes of abiraterone for prostate cancer: a systematic overview.

Liu M et al.

American Journal of Cancer Research, 2021

Genomic Instability in Circulating Tumor Cells.

Freitas MO et al.

Cancers, 2020

Combined Cell-free DNA and RNA Profiling of the Androgen Receptor: Clinical Utility of a Novel Multianalyte Liquid Biopsy Assay for Metastatic Prostate Cancer.

Fettke H et al.

European Urology, 2020

Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.

Kohli M et al.

Ebiomedicine, 2020

Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.

Ledet EM et al.

The Oncologist, 2020

Evaluation of the genomic alterations in the androgen receptor gene during treatment with high-dose testosterone for metastatic castrate-resistant prostate cancer.

Moses M et al.

Oncotarget, 2020

Towards precision oncology in advanced prostate cancer.

Ku SY et al.

Nature Reviews. Urology, 2019

Identification of single nucleotide variants using position-specific error estimation in deep sequencing data.

Kleftogiannis D et al.

Bmc Medical Genomics, 2019

Clinical determinants for successful circulating tumor DNA analysis in prostate cancer.

Schweizer MT et al.

The Prostate, 2019

TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Abiraterone or Enzalutamide Outcome in Metastatic Castration-Resistant Prostate Cancer.

De Laere B et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2019

Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer.

Sumiyoshi T et al.

Scientific Reports, 2019

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."