Varaico: Literature-Extracted Genetic Variants

Gene:AR
Variant:p.W742L
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AR

NM_000044.6:p.W742L

Associated Papers

Outcomes for Patients With SPOP Mutated Castration-Resistant Prostate Cancer (CRPC) Treated With an Androgen Receptor Pathway Inhibitor (ARPI).

Park JJ et al.

Clinical Genitourinary Cancer, 2026

Blood-Based Genomic Alteration Signature for Predicting Progression-Free Survival in De Novo Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Study.

Wang R et al.

Cancer Research Communications, 2025

41217768 (PubMed )
Supplement: crc-25-0384_supplementary_table_s2_suppst2.xlsx › Supplementary_Table_2

Circulating Tumor DNA as a Biomarker for Precision Medicine in Prostate Cancer: A Systematic Review.

Chanhih N et al.

International Journal of Molecular Sciences, 2025

Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C-CAT Database.

Tsukahara S et al.

Cancer Medicine, 2025

Comparison of androgen receptor mutation detection between plasma extracellular vesicle DNA and cell-free DNA and its relationship to prostate cancer prognosis.

Ding T et al.

Annals of Medicine, 2024

Structural perspectives on the androgen receptor, the elusive shape-shifter.

Johnson MJ et al.

Steroids, 2024

Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project.

Shiota M et al.

Bjc Reports, 2024

Circulating tumor DNA and tissue complementarily detect genomic alterations in metastatic hormone-sensitive prostate cancer.

Yang B et al.

Iscience, 2024

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity.

Wei Y et al.

Molecular Oncology, 2023

37584393 (PubMed )
Supplement: MOL2-17-2183-s002.xlsx › Table_S6

Circulating Tumor DNA Analysis on Metastatic Prostate Cancer with Disease Progression.

Bang S et al.

Cancers, 2023

37568814 (PubMed )
Supplement: cancers-15-03998-s001.zip › Supplementary_Table_S1_Patient_demographics.xlsx › Sheet1

Androgen receptor mutations modulate activation by 11-oxygenated androgens and glucocorticoids.

Snaterse G et al.

Prostate Cancer and Prostatic Diseases, 2023

Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.

Ravindran F et al.

Journal of Cancer Research and Clinical Oncology, 2023

A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.

Doamekpor SK et al.

Acta Crystallographica. Section F, Structural Biology Communications, 2023

A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.

Alegre-Martí A et al.

Science Advances, 2023

Genetic profiling of hormone-sensitive and castration-resistant prostate cancers and identification of genetic mutations prone to castration-resistant prostate cancer.

Wang Z et al.

Prostate Cancer and Prostatic Diseases, 2023

Simulating androgen receptor selection in designer yeast.

Zhang H et al.

Synthetic and Systems Biotechnology, 2022

Androgen receptor mutations for precision medicine in prostate cancer.

Shiota M et al.

Endocrine-related Cancer, 2022

Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors.

Radaeva M et al.

Cells, 2022

Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies.

Jacob A et al.

Cancers, 2021

Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms.

Tukachinsky H et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.

Ledet EM et al.

The Oncologist, 2020

Towards precision oncology in advanced prostate cancer.

Ku SY et al.

Nature Reviews. Urology, 2019

Detecting predictive androgen receptor modifications in circulating prostate cancer cells.

Steinestel J et al.

Oncotarget, 2019

Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer.

Sumiyoshi T et al.

Scientific Reports, 2019

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer.

Ponnusamy S et al.

Cancer Research, 2017

Clinical relevance of androgen receptor alterations in prostate cancer.

Jernberg E et al.

Endocrine Connections, 2017

Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions.

Dalal K et al.

Molecular Cancer Therapeutics, 2017

Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate.

Schweizer MT et al.

Oncotarget, 2016

Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer.

Wyatt AW et al.

Jama Oncology, 2016

Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.

Lallous N et al.

Genome Biology, 2016

Plasma AR and abiraterone-resistant prostate cancer.

Romanel A et al.

Science Translational Medicine, 2015

Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer.

O'Mahony OA et al.

Molecular Cancer Research : Mcr, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."