Associated Papers
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice.
Prakasam R et al.
Nature Communications, 2023
Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy.
Gogia N et al.
Frontiers in Molecular Neuroscience, 2022
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.
Scaramuzzino C et al.
Neuron, 2015
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.
Palazzolo I et al.
Neuron, 2009
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.
Palazzolo I et al.
Human Molecular Genetics, 2007
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