Varaico: Literature-Extracted Genetic Variants

Gene:ARAF
Variant:p.R52L
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ARAF

NM_001654.5:p.R52L

Associated Papers

DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signaling.

Takano K et al.

Life Science Alliance, 2025

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.

Su W et al.

Molecular Cell, 2022

Dominant-negative antagonists of the Ras-ERK pathway: DA-Raf and its related proteins generated by alternative splicing of Raf.

Endo T

Experimental Cell Research, 2020

DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.

Kanno E et al.

Experimental Cell Research, 2018

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

Rebocho AP et al.

Oncogene, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."