Varaico: Literature-Extracted Genetic Variants

Gene:ARAF
Variant:p.K336M
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ARAF

NM_001654.5:p.K336M

Associated Papers

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.

Yen I et al.

Nature, 2021

LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.

Monaco KA et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Somatic activating ARAF mutations in Langerhans cell histiocytosis.

Nelson DS et al.

Blood, 2014

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

Rebocho AP et al.

Oncogene, 2013

Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription.

Rauch J et al.

Cancer Research, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."