Varaico: Literature-Extracted Genetic Variants

Gene:ARHGEF12
Variant:p.S1288A
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ARHGEF12

NM_015313.3:p.S1288A

Associated Papers

Phosphorylation at S1288 of leukemia associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA.

Yang WS et al.

The Journal of Biological Chemistry, 2026

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.

Shi GX et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."