Varaico: Literature-Extracted Genetic Variants

Gene:ARIH1
Variant:p.C357S
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ARIH1

NM_005744.5:p.C357S

Associated Papers

Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress.

Kadowaki H et al.

Embo Reports, 2026

Biochemical analysis of PD-L1 ubiquitination by CRL3SPOP, ARIH1, and NEDD4 family ubiquitin ligases.

Xie G et al.

Structure (london, England : 1993), 2025

The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.

Xiong TC et al.

Nature Communications, 2022

Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.

Horn-Ghetko D et al.

Nature, 2021

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.

Kelsall IR et al.

The Journal of Biological Chemistry, 2019

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.

Bouchard JJ et al.

Molecular Cell, 2018

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.

Scott DC et al.

Cell, 2016

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR et al.

The Embo Journal, 2013

Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE et al.

Plos One, 2013

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Wenzel DM et al.

Nature, 2011

The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.

Ramírez J et al.

The Journal of Biological Chemistry, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."