Varaico: Literature-Extracted Genetic Variants

Gene:ARL2
Variant:p.Q70L
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ARL2

NM_001667.4:p.Q70L

Associated Papers

Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin-specific chaperones.

Seong Y et al.

Science (new York, N.y.), 2025

ARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia.

Huang Y et al.

Science Advances, 2024

Characterization of the small Arabidopsis thaliana GTPase and ADP-ribosylation factor-like 2 protein TITAN 5.

Mohr I et al.

Biorxiv : the Preprint Server for Biology, 2024

Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.

Quirion L et al.

Journal of Cell Science, 2024

38606629 (PubMed )
Supplement: joces-137-262140-s1.pdf

Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development.

Gerstner CD et al.

Cells, 2022

Roles for ELMOD2 and Rootletin in ciliogenesis.

Turn RE et al.

Molecular Biology of the Cell, 2021

The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.

Turn RE et al.

Molecular Biology of the Cell, 2020

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.

Moye AR et al.

Plos Genetics, 2019

Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.

Cai XB et al.

Clinical Genetics, 2019

ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E et al.

Molecular Biology of the Cell, 2019

ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2.

Schiavon CR et al.

Molecular Biology of the Cell, 2019

ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons.

Wright ZC et al.

Scientific Reports, 2018

The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space.

Newman LE et al.

Cellular Logistics, 2017

ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.

Wright ZC et al.

Human Molecular Genetics, 2016

The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.

Newman LE et al.

Plos One, 2014

The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei.

Price HP et al.

Molecular and Biochemical Parasitology, 2010

Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.

Zhang T et al.

Structure (london, England : 1993), 2009

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

Veltel S et al.

Febs Letters, 2008

ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

Bhamidipati A et al.

The Journal of Cell Biology, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."