Varaico: Literature-Extracted Genetic Variants

Gene:ATG7
Variant:p.C572S
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ATG7

NM_001349232.2:p.C572S

Associated Papers

KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions.

Takada S et al.

Embo Reports, 2025

ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.

Liu J et al.

Cell Reports, 2023

Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62.

Greer SU et al.

Scientific Reports, 2022

Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S.

Nitta A et al.

Biochemical and Biophysical Research Communications, 2019

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.

Tanida I et al.

Autophagy, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."