Associated Papers
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer.
Tewari AK et al.
Cell Reports, 2021
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.
Muralidharan SV et al.
Life Science Alliance, 2020
Oocytes progress beyond prophase in the presence of DNA damage.
Marangos P et al.
Current Biology : Cb, 2012
Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38.
Bhonde MR et al.
International Journal of Cancer, 2010
ATR dependent activation of Chk2.
Wang XQ et al.
Journal of Cellular Physiology, 2006
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
Maude SL et al.
Cancer Research, 2005
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
Gatei M et al.
The Journal of Biological Chemistry, 2003
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.
Feijoo C et al.
The Journal of Cell Biology, 2001
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