Varaico: Literature-Extracted Genetic Variants

Gene:ATM
Variant:p.R1437K
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ATM

NM_000051.4:p.R1437K

Associated Papers

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.

Schaufler D et al.

Npj Precision Oncology, 2021

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.

Yamamoto K et al.

Elife, 2016

27304073 (PubMed )
Supplement: elife-14709-supp1.xlsx › Supplementary_Information_1B

Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer.

Tavtigian SV et al.

American Journal of Human Genetics, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."