Associated Papers
Integrating evidence from protein domains to identify cancer driver mutations.
Ostroverkhova D et al.
Protein Science : a Publication of the Protein Society, 2026
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Classification of Gene Variants in a Danish Population with Suspected Predisposition to Hereditary Breast and/or Ovarian Cancer.
Munch AK et al.
Cancers, 2025
The kinase ATM delays Arabidopsis leaf senescence by stabilizing the phosphatase MKP2 in a phosphorylation-dependent manner.
Zhang Y et al.
The Plant Cell, 2025
ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.
Xie J et al.
Neuro-oncology, 2023
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress.
Howes AC et al.
Science Advances, 2023
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sakthikumar S et al.
Veterinary and Comparative Oncology, 2023
Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
McCann JJ et al.
Radiation Research, 2023
Targeted Mutational Analysis of Circulating Tumor DNA to Decipher Temporal Heterogeneity of High-Grade Serous Ovarian Cancer.
Paracchini L et al.
Cancers, 2022
ATM Kinase Dead: From Ataxia Telangiectasia Syndrome to Cancer.
Putti S et al.
Cancers, 2021
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Hescheler DA et al.
Frontiers in Endocrinology, 2021
ATM-associated signalling triggers the unfolded protein response and cell death in response to stress.
Hotokezaka Y et al.
Communications Biology, 2020
Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 Controls.
Momozawa Y et al.
Journal of the National Cancer Institute, 2020
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Schrader A et al.
Nature Communications, 2018
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Chen F et al.
Nature Communications, 2017
Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.
Liu X et al.
Cell Research, 2017
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.
Yamamoto K et al.
Elife, 2016
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
Yamamoto K et al.
The Journal of Cell Biology, 2012
ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.
Gamper AM et al.
The Journal of Biological Chemistry, 2012
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Young DB et al.
The Journal of Biological Chemistry, 2005
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Goodarzi AA et al.
The Embo Journal, 2004
Expression and assay of recombinant ATM.
Ziv Y et al.
Methods in Molecular Biology (clifton, N.j.), 2000