Varaico: Literature-Extracted Genetic Variants

Gene:BACE1
Variant:p.K501R
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BACE1

NM_012104.6:p.K501R

Associated Papers

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.

Bao J et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.

Yeates EF et al.

The Journal of Biological Chemistry, 2016

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Miyagawa T et al.

Human Molecular Genetics, 2016

Ubiquitin regulates GGA3-mediated degradation of BACE1.

Kang EL et al.

The Journal of Biological Chemistry, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."