Associated Papers
A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function.
Gelles JD et al.
Biorxiv : the Preprint Server for Biology, 2024
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme.
Sosinsky A et al.
Nature Medicine, 2024
38200255 (PubMed )
Supplement: 41591_2023_2682_MOESM3_ESM.xlsx › Table_S1
Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.
Lim D et al.
Plos Biology, 2023
BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.
Dengler MA et al.
Cell Death and Differentiation, 2021
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core.
Bloch NB et al.
Nature Communications, 2021
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Dengler MA et al.
Cell Reports, 2019
Ensemble Properties of Bax Determine Its Function.
Robin AY et al.
Structure (london, England : 1993), 2018
Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal.
Jarugumilli GK et al.
Acs Chemical Biology, 2018
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