Varaico: Literature-Extracted Genetic Variants

Gene:BCL2
Variant:p.G145E
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BCL2

NM_000633.3:p.G145E

Associated Papers

Role of the mitochondrial regulatory factor CHCHD2 in neurodegenerative diseases.

Guo X et al.

Frontiers in Neuroscience, 2025

Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma.

Al-Amer OM et al.

Cancers, 2023

36831357 (PubMed )
Supplement: cancers-15-01012-s001.zip › Table_S2.pdf

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.

Sangree AK et al.

Nature Communications, 2022

35288574 (PubMed )
Supplement: 41467_2022_28884_MOESM11_ESM.xlsx › NG-CBE_Library_Annotation

Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.

Raghav PK et al.

Molecular Genetics & Genomic Medicine, 2019

Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases.

Zhou ZD et al.

Molecular Neurobiology, 2017

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells.

Trisciuoglio D et al.

Cell Death and Differentiation, 2011

Structural conservation of residues in BH1 and BH2 domains of Bcl-2 family proteins.

Gurudutta GU et al.

Febs Letters, 2005

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry.

Huang DC et al.

The Embo Journal, 1997

Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.

Hengartner MO et al.

Nature, 1994

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."