Varaico: Literature-Extracted Genetic Variants

Gene:BCL2
Variant:p.R127Q
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BCL2

NM_000633.3:p.R127Q

Associated Papers

Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis.

Elamin G et al.

Frontiers in Genetics, 2024

39840282 (PubMed )
Supplement: Table1.docx

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.

Sangree AK et al.

Nature Communications, 2022

35288574 (PubMed )
Supplement: 41467_2022_28884_MOESM11_ESM.xlsx › NG-CBE_Library_Annotation

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.

Landau DA et al.

Nature Communications, 2017

29259203 (PubMed )
Supplement: 41467_2017_2329_MOESM6_ESM.xlsx › Supplementary_Data_4

The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.

Haupt K et al.

The Journal of Biological Chemistry, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."