Varaico: Literature-Extracted Genetic Variants

Gene:BCL2
Variant:p.G83E
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BCL2

NM_000633.3:p.G83E

Associated Papers

The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study.

Daneshparvar A et al.

Iranian Journal of Medical Sciences, 2025

Positive correlation between Bax and Bcl-2 gene polymorphisms with the risk of endometriosis: A case-control study.

Edalatian Kharrazi A et al.

International Journal of Reproductive Biomedicine, 2024

Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis.

Elamin G et al.

Frontiers in Genetics, 2024

39840282 (PubMed )
Supplement: Table1.docx

Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (Bcl-2/Bax) and Proinflammatory Cytokine (TNF-α/IL-8) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study.

Moawadh MS et al.

Current Issues in Molecular Biology, 2023

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.

Sangree AK et al.

Nature Communications, 2022

35288574 (PubMed )
Supplement: 41467_2022_28884_MOESM11_ESM.xlsx › NG-CBE_Library_Annotation

BAX gene (-248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil.

Cardoso-Duarte LCA et al.

The International Journal of Biological Markers, 2021

Functional Genetic Variants in ATG10 Are Associated with Acute Myeloid Leukemia.

Castro I et al.

Cancers, 2021

Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression.

Deng W et al.

Translational Oncology, 2018

30055346 (PubMed )
Supplement: mmc2.xlsx › Table_S1

Genetic association of the polymorphisms in apoptosis-related genes with osteoarthritis susceptibility in Chinese Han population.

Ma G et al.

International Journal of Clinical and Experimental Pathology, 2018

Potential impact of (rs 4645878) BAX promoter -248G>A and (rs 1042522) TP53 72Arg>pro polymorphisms on epithelial ovarian cancer patients.

Dholariya S et al.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2016

Polymorphisms of BCL2 and BAX Genes Associate with Outcomes in Advanced Non-small cell lung cancer Patients treated with platinum-based Chemotherapy.

Peng Y et al.

Scientific Reports, 2015

Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia.

Fernandes AT et al.

Apoptosis : an International Journal on Programmed Cell Death, 2015

Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India.

Cingeetham A et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2015

Role of polymorphisms in BCL-2 and BAX genes in modulating the risk of developing non-Hodgkin lymphoma.

Wang WL et al.

Leukemia & Lymphoma, 2014

Lack of association between Bax promoter (-248G>A) single nucleotide polymorphism and susceptibility towards cancer: evidence from a meta-analysis.

Sahu SK et al.

Plos One, 2013

The -938A/A genotype of BCL2 gene is associated with esophageal cancer.

Liu Z et al.

Medical Oncology (northwood, London, England), 2012

Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.

Chen K et al.

Carcinogenesis, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."