Varaico: Literature-Extracted Genetic Variants

Gene:BIRC5
Variant:p.T34A
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BIRC5

NM_001168.3:p.T34A

Associated Papers

Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders.

Miliotou AN et al.

Molecular Therapy. Nucleic Acids, 2021

34703653 (PubMed )
Supplement: mmc2.pdf

The survivin molecule as a double-edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer.

Rafatmanesh A et al.

Journal of Cellular Physiology, 2020

A direct interaction between survivin and myosin II is required for cytokinesis.

Babkoff A et al.

Journal of Cell Science, 2019

Resistance to FLT3 inhibitors in acute myeloid leukemia: Molecular mechanisms and resensitizing strategies.

Zhou J et al.

World Journal of Clinical Oncology, 2018

Differential localization and high expression of SURVIVIN splice variants in human embryonic stem cells but not in differentiated cells implicate a role for SURVIVIN in pluripotency.

Mull AN et al.

Stem Cell Research, 2014

Exploring the role of post-translational modifications on protein-protein interactions with survivin.

Nogueira-Ferreira R et al.

Archives of Biochemistry and Biophysics, 2013

Depletion of K-Ras promotes proteasome degradation of survivin.

Tecleab A et al.

Cell Cycle (georgetown, Tex.), 2013

[Oncogene and tumor suppressor gene].

Fukuda T et al.

Nihon Rinsho. Japanese Journal of Clinical Medicine, 2012

Transcriptional inhibition of p21WAF1/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: evidence for survivin acting as a transcription factor or co-factor.

Tang L et al.

Biochemical and Biophysical Research Communications, 2012

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.

Barrett RM et al.

Cell Cycle (georgetown, Tex.), 2011

Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs.

Kim Chiaw P et al.

Chemistry & Biology, 2009

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.

Yue Z et al.

The Journal of Cell Biology, 2008

Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis.

Connell CM et al.

Cancer Research, 2008

Survivin regulates the p53 tumor suppressor gene family.

Wang Z et al.

Oncogene, 2004

A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells.

Xu Y et al.

Dna and Cell Biology, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."