Associated Papers
Molecular mechanisms and therapeutic developments of BMPR2 in pulmonary arterial hypertension.
Chen P et al.
Respiratory Investigation, 2025
Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR).
Montani D et al.
American Journal of Respiratory and Critical Care Medicine, 2025
The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis.
Okhrimenko G et al.
Respiratory Research, 2025
Bone morphogenetic protein signalling in pulmonary arterial hypertension: revisiting the BMPRII connection.
Li W et al.
Biochemical Society Transactions, 2024
Imaging Features in BMPR2 Mutation-associated Pulmonary Arterial Hypertension.
Zhao Q et al.
Radiology, 2023
BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension.
Cuthbertson I et al.
Circulation Research, 2023
A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific.
Talati M et al.
Frontiers in Medicine, 2023
Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression.
Marinho Y et al.
Frontiers in Immunology, 2023
Impaired Interleukin-15 Signaling via BMPR2 Loss Drives Natural Killer Cell Deficiency and Pulmonary Hypertension.
Hilton LR et al.
Hypertension (dallas, Tex. : 1979), 2022
l-Carnitine therapy improves right heart dysfunction through Cpt1-dependent fatty acid oxidation.
Agrawal V et al.
Pulmonary Circulation, 2022
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis.
Aldred MA et al.
Circulation Research, 2022
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
van Uden D et al.
International Journal of Molecular Sciences, 2021
Targeting transforming growth factor-β receptors in pulmonary hypertension.
Guignabert C et al.
The European Respiratory Journal, 2021
Case Report: BMPR2-Targeted MinION Sequencing as a Tool for Genetic Analysis in Patients With Pulmonary Arterial Hypertension.
Takashima T et al.
Frontiers in Cardiovascular Medicine, 2021
Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.
Theilmann AL et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
BMPR2 Promoter Variants Effect Gene Expression in Pulmonary Arterial Hypertension Patients.
Song J et al.
Genes, 2020
4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension.
Dunmore BJ et al.
American Journal of Respiratory Cell and Molecular Biology, 2020
BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.
Hemnes AR et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2020
Molecular genetic framework underlying pulmonary arterial hypertension.
Southgate L et al.
Nature Reviews. Cardiology, 2020
Prevalence and clinical features of bone morphogenetic protein receptor type 2 mutation in Korean idiopathic pulmonary arterial hypertension patients: The PILGRIM explorative cohort.
Jang AY et al.
Plos One, 2020
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Morikawa M et al.
Science Signaling, 2019
BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension.
Chowdhury HM et al.
Human Molecular Genetics, 2019
TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension.
Tielemans B et al.
Drug Discovery Today, 2019
A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial Hypertension.
Barozzi C et al.
Scientific Reports, 2019
Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension.
Abbasi Y et al.
Molecular Genetics & Genomic Medicine, 2018
Genetics in pulmonary arterial hypertension in a large homogeneous Japanese population.
Gamou S et al.
Clinical Genetics, 2018
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
Gräf S et al.
Nature Communications, 2018
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.
Xing Y et al.
The European Respiratory Journal, 2018
Bone Morphogenetic Proteins in Vascular Homeostasis and Disease.
Goumans MJ et al.
Cold Spring Harbor Perspectives in Biology, 2018
Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Zabini D et al.
American Journal of Respiratory and Critical Care Medicine, 2018
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Vattulainen-Collanus S et al.
Communications Biology, 2018
Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.
Kim MJ et al.
Bmb Reports, 2017
Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension.
Egnatchik RA et al.
Pulmonary Circulation, 2017
Pulmonary extra-medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series.
Singh I et al.
Pulmonary Circulation, 2017
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Hurst LA et al.
Nature Communications, 2017
Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension.
Thompson AAR et al.
Trends in Molecular Medicine, 2017
Identification of genetic defects in pulmonary arterial hypertension by a new gene panel diagnostic tool.
Song J et al.
Clinical Science (london, England : 1979), 2016
Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.
Talati MH et al.
American Journal of Respiratory and Critical Care Medicine, 2016
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series).
Awad KS et al.
Pulmonary Circulation, 2016
Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.
Brittain EL et al.
Circulation, 2016
Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle.
van der Bruggen CE et al.
Circulation, 2016
Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.
Chen X et al.
Circulation, 2016
Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.
West JD et al.
Plos One, 2016
MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9).
Yuan H et al.
Plos One, 2016