Associated Papers
Biochemical Characterization of Full-Length Oncogenic BRAFV600E together with Molecular Dynamics Simulations Provide Insight into the Activation and Inhibition Mechanisms of RAF Kinases.
Cope N et al.
Chembiochem : a European Journal of Chemical Biology, 2019
The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF.
Kiel C et al.
Elife, 2016
Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.
Zheng G et al.
Bmc Cancer, 2015
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.
Holderfield M et al.
Cancer Cell, 2013
Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.
An L et al.
Scientific Reports, 2013
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