Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.K601E
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BRAF

NM_004333.6:p.K601E

Associated Papers

Mutational status of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): molecular analysis should be performed for NIFTPs with nuclear score 3.

Sako A et al.

Journal of Pathology and Translational Medicine, 2026

Outside canonical BRAF p.V600E Box: 7 novel BRAF gene fusions in BRAF p.V600E WT papillary thyroid carcinoma.

McGrath N et al.

Virchows Archiv : an International Journal of Pathology, 2026

Malignant struma ovarii: Advances in molecular pathogenesis, classification, diagnosis and treatment.

Lin W et al.

Histopathology, 2026

Genomic Profile of Non-Small Cell Lung Cancer in a Spanish Cohort: A 2-Year Descriptive Study Using Next-Generation Sequencing.

Carnero-Gregorio M et al.

Genes, 2026

The molecular profile of ovarian struma ovarii.

Calejero I et al.

Human Pathology, 2026

Braf-mutant metastatic non-small-cell lung cancer: Real world data from the Italian biomarker atlas database.

Sini C et al.

European Journal of Cancer (oxford, England : 1990), 2026

Mutational landscape of lung adenocarcinoma in Czechia.

Ambrozkiewicz F et al.

Cancer Treatment and Research Communications, 2026

Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial.

Rose AAN et al.

Nature Communications, 2026

Genomic determinants of response and resistance to pirtobrutinib in relapsed/refractory chronic lymphocytic leukemia.

Brown JR et al.

Blood, 2026

41055698 (PubMed )
Supplement: BLOOD_BLD-2024-027009-mmc5.xlsx › Sheet_1

Malignancy Risk, Molecular Mutations, and Surgical Outcomes of Thyroid Nodules Classified as Atypia of Undetermined Significance in the Bethesda System: A Comprehensive Analysis.

Bourque C et al.

Cytopathology : Official Journal of the British Society for Clinical Cytology, 2026

Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing.

Tessler I et al.

Clinical Endocrinology, 2026

Review of Genomic Drivers of Thyroid Cancer and Their Clinical Implications.

Mohammed S et al.

Genes, 2025

Nucleotide Substitution Biases in Related Cancer Driver Genes.

Khadre A et al.

International Journal of Molecular Sciences, 2025

Harnessing liquid biopsy to unveil RAS-MEK pathway somatic pathogenic variants in extracranial arterio-venous malformations.

Bhatia KD et al.

Communications Medicine, 2025

Routine sequencing of BRAF exon 15 improves therapeutic stratification for metastatic melanoma.

Chen YF et al.

American Journal of Clinical Pathology, 2025

Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing: An International Multicenter Study.

Lescuyer G et al.

The Journal of Molecular Diagnostics : Jmd, 2025

Clinical experience of using integrated whole genome and transcriptome sequencing as a framework for pediatric and adolescent acute myeloid leukemia diagnosis and risk assessment.

Voss RK et al.

Leukemia, 2025

41057686 (PubMed )
Supplement: 41375_2025_2774_MOESM2_ESM.xlsx › S3_-_SNVs__small_INDELS

Clinical Validation of a Rapid Automated Lymphoma Next-Generation Sequencing Panel.

Krigstein M et al.

Annals of Laboratory Medicine, 2025

41277019 (PubMed )
Supplement: ALM3692_Supple1.xlsx › Variant_Calls

Clinical and translational study of ivosidenib plus nivolumab in advanced solid tumors harboring IDH1 mutations.

Nguyen MK et al.

The Oncologist, 2025

Undifferentiated Melanoma: A Clinicopathologic and Gene Expression Analysis Study With Identification of HMGA2 as a Diagnostic Marker.

Fischer GM et al.

The American Journal of Surgical Pathology, 2025

Exploring the Genetic Landscape of Primary Marginal Zone Lymphoma of the Urinary Bladder.

Balestri I et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025

Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer.

Yang J et al.

Translational Lung Cancer Research, 2025

41234595 (PubMed )
Supplement: tlcr-14-10-4235-supplementary.pdf

Diversity of BRAF mutations in non-small cell lung cancer and implications on treatment.

Lu K et al.

Npj Precision Oncology, 2025

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6

High Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma.

Zambelli V et al.

Endocrine Pathology, 2025

41123735 (PubMed )
Supplement: 12022_2025_9883_MOESM4_ESM.xlsx › Foglio1

Malignant struma ovarii: clinicopathological and molecular features in a series of nine cases.

Yang X et al.

Virchows Archiv : an International Journal of Pathology, 2025

Primary sellar glomus tumor with BRAF K601E mutation: an aggressive tumor of uncertain malignant potential.

Mi B et al.

Brain Tumor Pathology, 2025

Targeted therapy for rare BRAF-mutated melanoma: Updated multicenter analysis and launch of a publicly accessible online outcome database.

Menzer C et al.

European Journal of Cancer (oxford, England : 1990), 2025

Somatic genetic alterations in the development and progression in thyroid tumors of follicular cells.

Calafato G et al.

European Thyroid Journal, 2025

Pathological Diagnosis of Thyroid Nodules with Preoperatively Detected TERT Promoter Mutations in the Absence of BRAFV600E: A Bi-Center Series of 52 Cases.

Alzumaili BA et al.

Thyroid : Official Journal of the American Thyroid Association, 2025

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S1

TP53 Alterations Are Associated With Poor Response to Lenvatinib in Patients With Advanced Thyroid Cancer.

Cirello V et al.

The Journal of Clinical Endocrinology and Metabolism, 2025

Invasive urothelial carcinoma with chordoid and myxoid features shows increased RAS/RAF pathway alterations.

Chan E et al.

Human Pathology, 2025

Combining Molecular Dynamics and Machine Learning to Predict Drug Resistance Causing Variants of BRAF in Colorectal Cancer.

Xie L et al.

Molecules (basel, Switzerland), 2025

[A Case of Metastatic Non-small Cell Lung Cancer with Rare BRAF p.L485_T488delinsF Mutation Treated with Dabrafenib and Trametinib].

Wang Y et al.

Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer, 2025

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.

de Bitter TJJ et al.

Scientific Reports, 2025

40830613 (PubMed )
Supplement: 41598_2025_13667_MOESM2_ESM.xlsx › Supplementary_Table_3

MutationAssessor in cBioPortal.

Su Y et al.

Biorxiv : the Preprint Server for Biology, 2025

40832239 (PubMed )
Supplement: media-1.pdf

Clinicopathological and molecular characteristics of papillary thyroid carcinoma with BRAF V600E and TERT promoter co-mutations.

Liu R et al.

Pathology, Research and Practice, 2025

Treatment outcome of NSCLC patients with BRAFnon-V600E mutations: a retrospective, multicentre analysis within the national Network Genomic Medicine (nNGM) Lung Cancer in Germany.

Kropf-Sanchen C et al.

Esmo Open, 2025

PIK3CB Inhibitor GSK2636771 in Cancers With PTEN Mutation/Deletion or Loss of PTEN Protein Expression: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols N and P.

Janku F et al.

Jco Precision Oncology, 2025

40865033 (PubMed )
Supplement: protocol1_PO-25-00265.pdf

Mutational Profiling Detection in FNAC Samples of Different Types of Thyroid Neoplasms Using Targeted NGS.

Liang R et al.

Cancers, 2025

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."