Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.T599I
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BRAF

NM_004333.6:p.T599I

Associated Papers

The molecular profile of ovarian struma ovarii.

Calejero I et al.

Human Pathology, 2026

Targeted therapy for rare BRAF-mutated melanoma: Updated multicenter analysis and launch of a publicly accessible online outcome database.

Menzer C et al.

European Journal of Cancer (oxford, England : 1990), 2025

PIK3CB Inhibitor GSK2636771 in Cancers With PTEN Mutation/Deletion or Loss of PTEN Protein Expression: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols N and P.

Janku F et al.

Jco Precision Oncology, 2025

40865033 (PubMed )
Supplement: protocol1_PO-25-00265.pdf

Lung Carcinoid Tumors With Potentially Actionable Genomic Alterations and Responses to Targeted Therapies.

Waliany S et al.

Clinical Lung Cancer, 2025

Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience.

Jha P et al.

The Journal of Liquid Biopsy, 2025

40503459 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S2

BRAF V600E in cancer: Exploring structural complexities, mutation profiles, and pathway dysregulation.

Bharti J et al.

Experimental Cell Research, 2025

BRAF Deletion in Adult Patients with Langerhans Cell Histiocytosis Correlates with Multisystem Disease and Poor Outcomes.

Lang M et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025

VarMeter2: An enhanced structure-based method for predicting pathogenic missense variants through Mahalanobis distance.

Ohno S et al.

Computational and Structural Biotechnology Journal, 2025

40160862 (PubMed )
Supplement: mmc2.xlsx › Sheet1

MET amplification correlates with poor prognosis and immunotherapy response as a subtype of melanoma: a multicenter retrospective study.

Cai X et al.

Bmc Cancer, 2024

39528978 (PubMed )
Supplement: 12885_2024_13163_MOESM1_ESM.xlsx › SNVs

Features and efficacy of triple-targeted therapy for patients with EGFR-mutant non-small-cell lung cancer with acquired BRAF alterations who are resistant to epidermal growth factor receptor tyrosine kinase inhibitors.

Li Y et al.

Esmo Open, 2024

Unveiling a rare BRAF mutation in minimally invasive follicular thyroid carcinoma: A case report.

Lee PS et al.

Medicine, 2024

Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.

Halik A et al.

Journal of Hematology & Oncology, 2024

39160538 (PubMed )
Supplement: 13045_2024_1590_MOESM1_ESM.xlsx › Suppl._Dataset_4_TS_SNV

BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC.

Provencio M et al.

Lung Cancer (amsterdam, Netherlands), 2024

Synchronous papillary and follicular thyroid carcinomas: the first retrospective cohort study and literature review.

Ye WD et al.

Translational Cancer Research, 2024

Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu XD et al.

Heliyon, 2024

38496837 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Diagnostic Utility of Next-Generation Sequencing in Circulating Free DNA and a Comparison With Matched Tissue in Gallbladder Carcinoma.

Mishra S et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2024

The Clinical, Genomic, and Transcriptomic Landscape of BRAF Mutant Cancers.

Kazandjian S et al.

Cancers, 2024

38275886 (PubMed )
Supplement: cancers-16-00445-s001.zip › Supplementary_Tables_S1-S18.xlsx › S1_Incidence_BRAF_Alterations

Role of gene sequencing in classifying struma ovarii: BRAF p.G469A mutation and TERT promoter alterations favour malignant struma ovarii.

Neyrand S et al.

Histopathology, 2024

Clinical features, genomic profiling, and outcomes of adult patients with unifocal Langerhans cell histiocytosis.

Lang M et al.

Orphanet Journal of Rare Diseases, 2023

Comprehensive genomic characterization of sporadic synchronous colorectal cancer: Implications for treatment optimization and clinical outcome.

Yang LP et al.

Cell Reports. Medicine, 2023

37794586 (PubMed )
Supplement: mmc4.xlsx › TCGA_path_oncokb

Unique Spectrum of Activating BRAF Alterations in Prostate Cancer.

Chehrazi-Raffle A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2023

37477913 (PubMed )
Supplement: ccr-23-1393_supplementary_data_1_suppds1.xlsx › Figure_2D

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).

Richards CE et al.

International Journal of Molecular Sciences, 2023

37445722 (PubMed )
Supplement: ijms-24-10545-s001.zip › PTPN11_paper_supplementary_tables_25042023.pdf

Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications.

Zhao Z et al.

Cancer Medicine, 2023

The Genomic Landscape of Melanoma and Its Therapeutic Implications.

Yang TT et al.

Genes, 2023

KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

Martianov AS et al.

International Journal of Molecular Sciences, 2023

36902296 (PubMed )
Supplement: ijms-24-04868-s001.zip › ijms-2214519-supplementary.pdf

Somatic mutation detection and KRAS amplification in testicular germ cell tumors.

Cabral ERM et al.

Frontiers in Oncology, 2023

Ongoing progress in BRAF-mutated non-small cell lung cancer.

Abdayem P et al.

Clinical Advances in Hematology & Oncology : H&o, 2022

RAF-MEK-ERK pathway in cancer evolution and treatment.

Ullah R et al.

Seminars in Cancer Biology, 2022

Targeted Next-Generation Sequencing-Based Multiple Gene Mutation Profiling of Patients with Rectal Adenocarcinoma Receiving or Not Receiving Neoadjuvant Chemoradiotherapy.

Chang YK et al.

International Journal of Molecular Sciences, 2022

36142267 (PubMed )
Supplement: ijms-23-10353-s001.zip › ijms-1910530-supplementary.pdf

Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes.

Di Federico A et al.

Cancers, 2022

35884534 (PubMed )
Supplement: cancers-14-03472-s001.zip › cancers-1806422-supplementary.pdf

Targeting BRAF-mutant non-small cell lung cancer: Current status and future directions.

Riudavets M et al.

Lung Cancer (amsterdam, Netherlands), 2022

Clinical characteristics and survival of children with hypertrophic cardiomyopathy in China: A multicentre retrospective cohort study.

Chan W et al.

Eclinicalmedicine, 2022

35747179 (PubMed )
Supplement: mmc1.pdf

Mutational landscape of normal epithelial cells in Lynch Syndrome patients.

Lee BCH et al.

Nature Communications, 2022

35581206 (PubMed )
Supplement: 41467_2022_29920_MOESM3_ESM.xlsx › SD7

Melanoma with genetic alterations beyond the BRAFV600 mutation: management and new insights.

Awada G et al.

Current Opinion in Oncology, 2022

Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Chen S et al.

Bmc Genomics, 2022

35031014 (PubMed )
Supplement: 12864_2021_8289_MOESM1_ESM.xlsx › Table_S1

High frequency of BRAF mutations in primary mucinous ovarian carcinoma of Taiwanese patients.

Chao WR et al.

Taiwanese Journal of Obstetrics & Gynecology, 2021

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.

Sun H et al.

Nature Communications, 2021

34429404 (PubMed )
Supplement: 41467_2021_25177_MOESM8_ESM.xlsx › Sheet1

Co-mutations of epidermal growth factor receptor and BRAF in Chinese non-small cell lung cancer patients.

Peng P et al.

Annals of Translational Medicine, 2021

Molecular Alterations in Relation to Histopathological Characteristics in a Large Series of Pediatric Papillary Thyroid Carcinoma from a Single Institution.

Macerola E et al.

Cancers, 2021

Meta-Analysis and Systematic Review of the Genomics of Mucosal Melanoma.

Broit N et al.

Molecular Cancer Research : Mcr, 2021

High BRAF variant allele frequencies are associated with distinct pathological features and responsiveness to target therapy in melanoma patients.

Berrino E et al.

Esmo Open, 2021

Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Asselta R et al.

Thoracic Cancer, 2021

33704917 (PubMed )
Supplement: TCA-12-1271-s003.xls › Foglio1

High sensitivity sanger sequencing detection of BRAF mutations in metastatic melanoma FFPE tissue specimens.

Cheng LY et al.

Scientific Reports, 2021

33907234 (PubMed )
Supplement: 41598_2021_88391_MOESM1_ESM.pdf

Clinical, Pathological and Prognostic Features of Rare BRAF Mutations in Metastatic Colorectal Cancer (mCRC): A Bi-Institutional Retrospective Analysis (REBUS Study).

Calegari MA et al.

Cancers, 2021

Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix.

Takayanagi D et al.

Cancers, 2021

33802174 (PubMed )
Supplement: cancers-13-01215-s001.zip › Supplymentary_files › Supplymental_table.xlsx › TableS1

Development of BRAF V600E Mutation in NRAS Q61L Mutated Rectal Cancer.

Cao MN et al.

Annals of Clinical and Laboratory Science, 2021

A Narrative Review of Genetic Alterations in Primary Thyroid Epithelial Cancer.

Romei C et al.

International Journal of Molecular Sciences, 2021

Musculo-skeletal phenotype of Costello syndrome and cardio-facio-cutaneous syndrome: insights on the functional assessment status.

Leoni C et al.

Orphanet Journal of Rare Diseases, 2021

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."