Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.L597I
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BRAF

NM_004333.6:p.L597I

Associated Papers

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

Correlation of genetic alterations by whole-exome sequencing with clinical outcomes of glioblastoma patients from the Lebanese population.

Saadeh FS et al.

Plos One, 2020

33237934 (PubMed )
Supplement: pone.0242793.s003.xlsx › Sheet1

Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing.

Guo Q et al.

Molecular Cancer, 2018

30153823 (PubMed )
Supplement: 12943_2018_875_MOESM3_ESM.xlsx › Table_S2_ctDNA_Alterations

The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF.

Kiel C et al.

Elife, 2016

26744778 (PubMed )
Supplement: elife-12814-supp1.xlsx › input_random_forest

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.

Andreadi C et al.

Genes & Development, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."