Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.E545A
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BRAF

NM_004333.6:p.E545A

Associated Papers

Decoding the functional impact of the cancer genome through protein-protein interactions.

Fu H et al.

Nature Reviews. Cancer, 2025

Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.

Yasin F et al.

The Oncologist, 2024

Detection of genetic mutations in 855 cases of papillary thyroid carcinoma by next generation sequencing and its clinicopathological features.

Shi D et al.

Diagnostic Pathology, 2024

Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa Phase II Trial, AIO KRK 0212).

Stahler A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

38289994 (PubMed )
Supplement: ccr-23-3023_supplementary_data_1_suppds1.pdf

Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients.

Starita N et al.

International Journal of Cancer, 2022

Genomic landscape of lung cancer in the young.

Ruiz R et al.

Frontiers in Oncology, 2022

36263208 (PubMed )
Supplement: DataSheet_2.pdf

NGS-based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment.

Sánchez-Herrero E et al.

Molecular Oncology, 2021

34058070 (PubMed )
Supplement: MOL2-15-2363-s001.docx

Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Lee Y et al.

Cancer Research and Treatment, 2021

The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Fu X et al.

Frontiers in Oncology, 2021

Divergent molecular profile of PIK3CA gene in arsenic-associated bladder carcinoma.

Basu M et al.

Mutagenesis, 2020

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.

Le Cras TD et al.

Angiogenesis, 2020

High Frequency of PIK3CA Mutations in Low-Grade Serous Ovarian Carcinomas of Japanese Patients.

Ishibashi T et al.

Diagnostics (basel, Switzerland), 2019

Mutation profiling of cancer drivers in Brazilian colorectal cancer.

Dos Santos W et al.

Scientific Reports, 2019

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Kaur P et al.

Scientific Reports, 2019

30728399 (PubMed )
Supplement: 41598_2018_37574_MOESM1_ESM.pdf

Racial Disparities in the Molecular Landscape of Cancer.

Heath EI et al.

Anticancer Research, 2018

Long-term clinical benefit from salvage EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer patients with EGFR wild-type tumors.

Koinis F et al.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2018

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.

Magliacane G et al.

Oncotarget, 2015

Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.

Lu W et al.

Molecular Medicine Reports, 2015

Molecular spectrum of PIK3CA gene mutations in patients with nonsmall-cell lung cancer in Turkey.

Ekinci S et al.

Genetic Testing and Molecular Biomarkers, 2015

Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer.

Zhang QY et al.

Mutation Research, 2014

Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients.

Corso G et al.

European Journal of Human Genetics : Ejhg, 2013

Emerging landscape of oncogenic signatures across human cancers.

Ciriello G et al.

Nature Genetics, 2013

24071851 (PubMed )
Supplement: NIHMS550190-supplement-Supplementary_Figures.pdf

Oncogenic mutations in extramammary Paget's disease and their clinical relevance.

Kang Z et al.

International Journal of Cancer, 2013

Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.

Palomba G et al.

Journal of Translational Medicine, 2012

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients.

Perrone F et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2009

Alternate molecular genetic pathways in ovarian carcinomas of common histological types.

Willner J et al.

Human Pathology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."