Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.N486_T491del0
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BRAF

NM_004333.6:p.N486_T491del0

Associated Papers

A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: The AVATAR Trial.

Sarno F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025

39540844 (PubMed )
Supplement: ccr-23-4026_supplementary_table_s3_suppts3.xlsx › Table

Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children.

Tang X et al.

Cancer Medicine, 2024

MET amplification correlates with poor prognosis and immunotherapy response as a subtype of melanoma: a multicenter retrospective study.

Cai X et al.

Bmc Cancer, 2024

39528978 (PubMed )
Supplement: 12885_2024_13163_MOESM1_ESM.xlsx › SNVs

Clinical phenotype of adult-onset systemic histiocytosis harboring BRAF in-frame deletions.

Papo M et al.

Haematologica, 2024

Chemotherapy-free treatment targeting fusions and driver mutations in KRAS wild-type pancreatic ductal adenocarcinoma, a case series.

Mehdi M et al.

Therapeutic Advances in Medical Oncology, 2024

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.

Kemps PG et al.

Blood Advances, 2023

36083130 (PubMed )
Supplement: BLOODA_ADV-2022-007947-mmc1.pdf

Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy.

Viol F et al.

Cellular Oncology (dordrecht, Netherlands), 2022

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers.

Pham NA et al.

Scientific Reports, 2021

34011980 (PubMed )
Supplement: 41598_2021_90049_MOESM1_ESM.pdf

Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutation.

Ren R et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2021

Circulating Tumor DNA Analyses Predict Disease Recurrence in Non-Muscle-Invasive Bladder Cancer.

Zhang J et al.

Frontiers in Oncology, 2021

33996580 (PubMed )
Supplement: Table_1.xlsx › Sheet1

Genetic landscape of adult Langerhans cell histiocytosis with lung involvement.

Jouenne F et al.

The European Respiratory Journal, 2020

Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma.

Wrzeszczynski KO et al.

Cold Spring Harbor Molecular Case Studies, 2019

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.

Durham BH et al.

Nature Medicine, 2019

31768065 (PubMed )
Supplement: NIHMS1541330-supplement-1.pdf

Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules.

Ren Y et al.

Frontiers in Oncology, 2019

31058088 (PubMed )
Supplement: Data_Sheet_1.PDF

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Aguirre AJ et al.

Cancer Discovery, 2018

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia.

Nadeu F et al.

Leukemia, 2018

28924241 (PubMed )
Supplement: leu2017291x4.xlsx › Table_S7
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."