Varaico: Literature-Extracted Genetic Variants

Gene:BRAF
Variant:p.S467L
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BRAF

NM_004333.6:p.S467L

Associated Papers

Exploring Molecular Characteristics and Therapeutic Strategies for Primary Sinonasal Mucosal Melanoma With Distant Metastasis.

Ren D et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2025

Targeted therapy for rare BRAF-mutated melanoma: Updated multicenter analysis and launch of a publicly accessible online outcome database.

Menzer C et al.

European Journal of Cancer (oxford, England : 1990), 2025

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S5

Combining Molecular Dynamics and Machine Learning to Predict Drug Resistance Causing Variants of BRAF in Colorectal Cancer.

Xie L et al.

Molecules (basel, Switzerland), 2025

Prevalence and breakdown of KRAS driver mutations in a large UK non-small cell lung cancer cohort.

Niesner ICC et al.

Journal of Clinical Pathology, 2025

The NF1 gene mutations and co-mutations in lung adenocarcinomas with brain metastasis.

Kahraman-Cetin N et al.

Indian Journal of Pathology & Microbiology, 2025

BRAF V600E in cancer: Exploring structural complexities, mutation profiles, and pathway dysregulation.

Bharti J et al.

Experimental Cell Research, 2025

BRAF V600E and Non-V600E Mutations in RAS Wild-Type Metastatic Colorectal Cancer: Prognostic and Therapeutic Insights from a Nationwide, Multicenter, Observational Study (J-BROS).

Taniguchi H et al.

Cancers, 2025

Features and efficacy of triple-targeted therapy for patients with EGFR-mutant non-small-cell lung cancer with acquired BRAF alterations who are resistant to epidermal growth factor receptor tyrosine kinase inhibitors.

Li Y et al.

Esmo Open, 2024

Genomic profiling of a skin adnexal carcinomas cohort using a comprehensive high-throughput sequencing approach.

Louveau B et al.

The British Journal of Dermatology, 2024

A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation.

Yaeger R et al.

Cancer Discovery, 2024

38691346 (PubMed )
Supplement: cd-24-0024_table_s3_suppst3.pdf

Comprehensive insights on genetic alterations and immunotherapy prognosis in Chinese melanoma patients.

Jia DD et al.

Scientific Reports, 2024

Concurrent NRAS-BRAF variants in metastatic colorectal cancer: a Tunisian case report.

Douik H et al.

Anti-cancer Drugs, 2024

Molecular Characterization of Advanced-Stage Melanomas in Clinical Practice Using a Laboratory-Developed Next-Generation Sequencing Panel.

Maloberti T et al.

Diagnostics (basel, Switzerland), 2024

Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations.

Haugh AM et al.

Cancers, 2024

The Clinical, Genomic, and Transcriptomic Landscape of BRAF Mutant Cancers.

Kazandjian S et al.

Cancers, 2024

38275886 (PubMed )
Supplement: cancers-16-00445-s001.zip › Supplementary_Tables_S1-S18.xlsx › S1_Incidence_BRAF_Alterations

Follicular cell-derived thyroid carcinomas harboring novel genetic BRAFNON-V600E mutations: real-world data obtained using a multigene panel.

von Ammon JL et al.

Archives of Endocrinology and Metabolism, 2024

BRAF mutations and concurrent alterations in patients with soft tissue sarcoma.

Kobayashi H et al.

Genes, Chromosomes & Cancer, 2023

Network-based prediction approach for cancer-specific driver missense mutations using a graph neural network.

Hatano N et al.

Bmc Bioinformatics, 2023

Circulating Tumor DNA: A Promising Biomarker for Predicting Recurrence in Patients with BRAF-Negative Melanoma.

Aoude LG et al.

The Journal of Molecular Diagnostics : Jmd, 2023

BRAF Non-V600 Mutations in Metastatic Colorectal Cancer.

Liu J et al.

Cancers, 2023

Clinical characteristics and treatment outcomes of non-V600 E/K BRAF mutant melanoma patients: a single-institution experience.

Comito F et al.

Melanoma Research, 2022

Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group.

Vranic S et al.

Acta Medica Academica, 2022

RAF-MEK-ERK pathway in cancer evolution and treatment.

Ullah R et al.

Seminars in Cancer Biology, 2022

BRAF and MEK Targeted Therapies in Pediatric Central Nervous System Tumors.

Talloa D et al.

Cancers, 2022

Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes.

Di Federico A et al.

Cancers, 2022

35884534 (PubMed )
Supplement: cancers-14-03472-s001.zip › cancers-1806422-supplementary.pdf

Detection of oncogenic and clinically actionable mutations in cancer genomes critically depends on variant calling tools.

Garcia-Prieto CA et al.

Bioinformatics (oxford, England), 2022

35512388 (PubMed )
Supplement: btac306_supplementary_data.zip › Supplementary_files.zip › Supplementary_files › Supplementary_file_7.xlsx › Sheet1

Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Sobahy TM et al.

Bmc Medical Genomics, 2022

35468810 (PubMed )
Supplement: 12920_2022_1235_MOESM3_ESM.xlsx › OncoKB_unspecified-alterations.

Immune biomarkers and response to checkpoint inhibition of BRAFV600 and BRAF non-V600 altered lung cancers.

Murciano-Goroff YR et al.

British Journal of Cancer, 2022

Spectrum of BRAF Aberrations and Its Potential Clinical Implications: Insights From Integrative Pan-Cancer Analysis.

Yi Q et al.

Frontiers in Bioengineering and Biotechnology, 2022

35910024 (PubMed )
Supplement: Table2.XLSX › table

Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.

Georgoulias G et al.

Frontiers in Immunology, 2022

36389735 (PubMed )
Supplement: Table_7.xlsx › BRAF

Genomic Landscape of Malignant Peripheral Nerve Sheath Tumor‒Like Melanoma.

Muniz TP et al.

The Journal of Investigative Dermatology, 2021

BRN2 is a non-canonical melanoma tumor-suppressor.

Hamm M et al.

Nature Communications, 2021

34140478 (PubMed )
Supplement: 41467_2021_23973_MOESM1_ESM.pdf

Spatially interacting phosphorylation sites and mutations in cancer.

Huang KL et al.

Nature Communications, 2021

33875650 (PubMed )
Supplement: 41467_2021_22481_MOESM4_ESM.xlsx › TableS5.ActMutationClusters

SPRED1 deletion confers resistance to MAPK inhibition in melanoma.

Ablain J et al.

The Journal of Experimental Medicine, 2021

Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.

Zhao Y et al.

Jama Network Open, 2021

Prevalence of class I-III BRAF mutations among 114,662 cancer patients in a large genomic database.

Owsley J et al.

Experimental Biology and Medicine (maywood, N.j.), 2021

Retrospective Case Series Analysis of RAF Family Alterations in Pancreatic Cancer: Real-World Outcomes From Targeted and Standard Therapies.

Hendifar A et al.

Jco Precision Oncology, 2021

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

A Melanoma-Tailored Next-Generation Sequencing Panel Coupled with a Comprehensive Analysis to Improve Routine Melanoma Genotyping.

Louveau B et al.

Targeted Oncology, 2020

BRAF: A Two-Faced Janus.

Pisapia P et al.

Cells, 2020

Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks.

Śmiech M et al.

Genes, 2020

Association between BRAF mutant classification and the efficacy of pemetrexed-based chemotherapy in Chinese advanced non-small cell lung cancer patients: a multicenter retrospective study.

Lei L et al.

Translational Cancer Research, 2020

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns.

Mateo L et al.

Genome Medicine, 2020

32907621 (PubMed )
Supplement: 13073_2020_774_MOESM1_ESM.zip › SupplementaryTables › TableS2.xlsx › Driver_Mutations

Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.

Diefenbach RJ et al.

Cancers, 2020

32785074 (PubMed )
Supplement: cancers-12-02228-s001.zip › TableS5PatientMutationsIdentified.xlsx › Sheet1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."