Associated Papers
The BRCA1- RAD51 Axis Regulates SCAI/REV3 Dependent Replication Fork Maintenance.
Unterseher C et al.
Biorxiv : the Preprint Server for Biology, 2025
Triple-Action Therapy: Combining Machine Learning, Docking, and Dynamics to Combat BRCA1-Mutated Breast Cancer.
Zainulabidin AA et al.
Molecular Biotechnology, 2025
Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution.
Mangkusaputra V et al.
Nucleic Acids Research, 2025
ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence.
Ramadane-Morchadi L et al.
American Journal of Human Genetics, 2025
Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers.
Gracia B et al.
Cell Reports, 2024
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Tsukada K et al.
Molecular Cell, 2024
Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population.
Qin Z et al.
International Journal of Cancer, 2023
The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops.
Chang CW et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Variomes: a high recall search engine to support the curation of genomic variants.
Pasche E et al.
Bioinformatics (oxford, England), 2022
Erratum: Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome.
Unknown Author
Frontiers in Oncology, 2022
Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites.
Sherker A et al.
Embo Reports, 2021
Towards a New, Endophenotype-Based Strategy for Pathogenicity Prediction in BRCA1 and BRCA2: In Silico Modeling of the Outcome of HDR/SGE Assays for Missense Variants.
Özkan S et al.
International Journal of Molecular Sciences, 2021
Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome.
Fanale D et al.
Frontiers in Oncology, 2021
Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation.
Sinha S et al.
Computational and Structural Biotechnology Journal, 2020
CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.
Batenburg NL et al.
Nucleic Acids Research, 2019
Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.
Petitalot A et al.
Molecular Cancer Research : Mcr, 2019
Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
Yasuhara T et al.
Cell, 2018
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.
Periasamy J et al.
Cell Chemical Biology, 2018
And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance.
Chen Y et al.
Nucleic Acids Research, 2017
Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domain.
White ER et al.
Acs Chemical Biology, 2015
Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.
Martelotto LG et al.
Genome Biology, 2014
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.
Li M et al.
Cancer Cell, 2013
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
Escribano-Díaz C et al.
Molecular Cell, 2013
BRCT domains: phosphopeptide binding and signaling modules.
Rodriguez MC et al.
Frontiers in Bioscience : a Journal and Virtual Library, 2008
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.
Botuyan MV et al.
Structure (london, England : 1993), 2004
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Clapperton JA et al.
Nature Structural & Molecular Biology, 2004
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.
Williams RS et al.
Nature Structural & Molecular Biology, 2004