Varaico: Literature-Extracted Genetic Variants

Gene:BRCA1
Variant:p.K109R
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BRCA1

NM_007294.4:p.K109R

Associated Papers

Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population.

Qin Z et al.

International Journal of Cancer, 2023

36385461 (PubMed )
Supplement: IJC-152-1159-s001.xlsx › Indian

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.

Sangree AK et al.

Nature Communications, 2022

35288574 (PubMed )
Supplement: 41467_2022_28884_MOESM10_ESM.xlsx › variant-ABE_library_annotation

A Provocative Molecular Link between Mammographic Density and BRCA1-loss associated TNBC.

Xu J et al.

International Journal of Human Genetics and Genetic Disorders, 2019

A novel Ubc9 -dependent pathway regulates SIRT1- ER-α Axis and BRCA1-associated TNBC lung metastasis.

Xu J et al.

Integrative Molecular Medicine, 2017

BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells.

Xu J et al.

International Journal of Chronic Diseases & Therapy, 2016

BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9.

Qin Y et al.

American Journal of Cancer Research, 2012

Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.

Qin Y et al.

Journal of Cellular Physiology, 2011

The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer.

Liu CL et al.

Oncology, 2007

A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells.

Xu J et al.

Enliven. Challenges in Cancer Detection and Therapy, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."