Associated Papers
BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair.
Jimenez-Sainz J et al.
Elife, 2022
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.
Schipani F et al.
International Journal of Molecular Sciences, 2022
Identification of deleterious variants of uncertain significance in BRCA2 BRC4 repeat through molecular dynamics simulations.
Sinha S et al.
Briefings in Functional Genomics, 2022
BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability.
Han J et al.
Nature Communications, 2017
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Yata K et al.
Cell Reports, 2014
24835992 (PubMed )
Supplement: mmc1.pdf
Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3.
Yoshikawa Y et al.
Plos One, 2012
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.
Cole DJ et al.
Plos Computational Biology, 2011
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51.
Ochiai K et al.
Febs Letters, 2011
Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51.
Tal A et al.
Journal of Molecular Biology, 2009
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Carreira A et al.
Cell, 2009
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Pellegrini L et al.
Nature, 2002
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