Varaico: Literature-Extracted Genetic Variants

Gene:BRCA2
Variant:p.L1545F
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BRCA2

NM_000059.4:p.L1545F

Associated Papers

Identification of deleterious variants of uncertain significance in BRCA2 BRC4 repeat through molecular dynamics simulations.

Sinha S et al.

Briefings in Functional Genomics, 2022

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.

Cole DJ et al.

Plos Computational Biology, 2011

Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.

Nomme J et al.

Journal of Medicinal Chemistry, 2010

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