Varaico: Literature-Extracted Genetic Variants

Gene:BRCA2
Variant:p.H1731L
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BRCA2

NM_000059.4:p.H1731L

Associated Papers

CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors.

Zouggari N et al.

Frontiers in Oncology, 2025

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM.

Ito F et al.

Nature Communications, 2024

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma.

Xu Y et al.

Cell Reports, 2023

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Stordal B et al.

Molecular Oncology, 2013

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

Ng CK et al.

The Journal of Pathology, 2012

Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma.

Sakai W et al.

Cancer Research, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."