Associated Papers
Variomes: a high recall search engine to support the curation of genomic variants.
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Bioinformatics (oxford, England), 2022
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A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays.
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Npj Genomic Medicine, 2020
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C.
Chen X et al.
Cell Death & Disease, 2020
32980867 (PubMed )
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A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.
Shailani A et al.
Medical Oncology (northwood, London, England), 2018
Functional assays for analysis of variants of uncertain significance in BRCA2.
Guidugli L et al.
Human Mutation, 2014
A classification model for BRCA2 DNA binding domain missense variants based on homology-directed repair activity.
Guidugli L et al.
Cancer Research, 2013
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Biswas K et al.
Human Molecular Genetics, 2012
A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin.
Warren CR et al.
Experimental Cell Research, 2011
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