Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Joseph RE et al.
Elife, 2024
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Joseph RE et al.
Biorxiv : the Preprint Server for Biology, 2024
Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.
Kueffer LE et al.
Biochemistry, 2024
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Hescheler DA et al.
Frontiers in Endocrinology, 2021
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Duarte DP et al.
Nature Communications, 2020
Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.
Wist M et al.
The Journal of Biological Chemistry, 2020
A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.
Boyken SE et al.
Journal of Molecular Biology, 2014
The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment.
Block H et al.
International Reviews of Immunology, 2012
Identification of an allosteric signaling network within Tec family kinases.
Joseph RE et al.
Journal of Molecular Biology, 2010
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Marcotte DJ et al.
Protein Science : a Publication of the Protein Society, 2010
Activation mechanism and steady state kinetics of Bruton's tyrosine kinase.
Dinh M et al.
The Journal of Biological Chemistry, 2007
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.
Yu L et al.
The Journal of Biological Chemistry, 2006
Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells.
Yang EJ et al.
The Journal of Biological Chemistry, 2004
Phosphorylation of Bruton's tyrosine kinase by c-Abl.
Bäckesjö CM et al.
Biochemical and Biophysical Research Communications, 2002
Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.
Vargas L et al.
The Journal of Biological Chemistry, 2002
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
Mao C et al.
The Journal of Biological Chemistry, 2001
Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.
Mahajan S et al.
The Journal of Biological Chemistry, 2001
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.
Saito K et al.
The Journal of Biological Chemistry, 2001
Nucleocytoplasmic shuttling of Bruton's tyrosine kinase.
Mohamed AJ et al.
The Journal of Biological Chemistry, 2000
Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
Guo B et al.
Immunity, 2000
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
Fluckiger AC et al.
The Embo Journal, 1998
Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
Li T et al.
Oncogene, 1997
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function.
Kurosaki T et al.
The Journal of Biological Chemistry, 1997
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Park H et al.
Immunity, 1996
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Li T et al.
Immunity, 1995