Varaico: Literature-Extracted Genetic Variants

Gene:BTK
Variant:p.T474A
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BTK

NM_000061.3:p.T474A

Associated Papers

BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib.

Estupiñán HY et al.

Leukemia, 2021

Resistance Mutations to BTK Inhibitors Originate From the NF-κB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway.

Smith CIE et al.

Frontiers in Immunology, 2021

Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines.

Kozaki R et al.

Cancers, 2018

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.

Sharma S et al.

Oncotarget, 2016

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

Davis RE et al.

Nature, 2010

Naturally occurring Bruton's tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model.

Pérez de Diego R et al.

Clinical and Experimental Immunology, 2008

[Genetic diagnosis of patients with primary agammaglobulinemia treated at third level peruvian centers].

Matos-Benavides E et al.

Revista Peruana De Medicina Experimental Y Salud Publica, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."