Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Case report: A panorama gene profile of ovarian cancer metastasized to axillary lymph node.
Xia Y et al.
Frontiers in Immunology, 2025
The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas.
Mehra S et al.
International Journal of Molecular Sciences, 2024
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function.
Estupiñán HY et al.
Blood Advances, 2024
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Montoya S et al.
Science (new York, N.y.), 2024
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Bame E et al.
Clinical & Translational Immunology, 2021
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Duarte DP et al.
Nature Communications, 2020
Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.
Wist M et al.
The Journal of Biological Chemistry, 2020
The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment.
Block H et al.
International Reviews of Immunology, 2012
Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.
Kersseboom R et al.
European Journal of Immunology, 2010
Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement.
Kersseboom R et al.
Journal of Immunology (baltimore, Md. : 1950), 2006
Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.
Guo S et al.
International Immunology, 2006
Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.
Middendorp S et al.
Journal of Immunology (baltimore, Md. : 1950), 2003
Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.
Kersseboom R et al.
The Journal of Experimental Medicine, 2003
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
Nore BF et al.
Biochimica Et Biophysica Acta, 2003
Phosphorylation of Bruton's tyrosine kinase by c-Abl.
Bäckesjö CM et al.
Biochemical and Biophysical Research Communications, 2002
Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
Guo B et al.
Immunity, 2000
Tec kinases: a family with multiple roles in immunity.
Yang WC et al.
Immunity, 2000
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
Fluckiger AC et al.
The Embo Journal, 1998
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function.
Kurosaki T et al.
The Journal of Biological Chemistry, 1997
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Park H et al.
Immunity, 1996