Associated Papers
The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes.
Zerillo L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
Similar Molecular Features in Two Cases of CARD14-Associated Papulosquamous Eruption.
Wang Y et al.
The Australasian Journal of Dermatology, 2025
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.
Lee CC et al.
Trends in Immunology, 2025
Clinical Characteristics of CARD14-Associated Papulosquamous Eruption and Evaluation of Therapeutic Efficacy of Secukinumab.
Zhao X et al.
Journal of Inflammation Research, 2025
Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.
Iliaki S et al.
Biochemical Pharmacology, 2024
CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.
O'Sullivan PA et al.
The Biochemical Journal, 2024
Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.
DeVore SB et al.
Cell Reports, 2024
Targeting IL-1 controls refractory pityriasis rubra pilaris.
Schmauch E et al.
Science Advances, 2024
Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family.
Staal J et al.
The Febs Journal, 2024
Pathophysiology of generalized pustular psoriasis.
Young KZ et al.
Experimental Dermatology, 2023
Genetic underpinnings of the psoriatic spectrum.
Hüffmeier U et al.
Medizinische Genetik : Mitteilungsblatt Des Berufsverbandes Medizinische Genetik E.v, 2023
CARD14 Missense Variant Underlying CARD14-Associated Papulosquamous Eruption with Beneficial Response to Secukinumab.
Dai S et al.
Jid Innovations : Skin Science From Molecules to Population Health, 2023
The role of the CBM complex in allergic inflammation and disease.
DeVore SB et al.
The Journal of Allergy and Clinical Immunology, 2022
Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis.
Suleman S et al.
International Journal of Molecular Sciences, 2022
Role of Interleukin 36 in Generalised Pustular Psoriasis and Beyond.
Sugiura K
Dermatology and Therapy, 2022
Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.
Aksentijevich I et al.
Nature Reviews. Rheumatology, 2021
An update on genetic basis of generalized pustular psoriasis (Review).
Zhou J et al.
International Journal of Molecular Medicine, 2021
Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner.
Zhang S et al.
Journal of Immunology (baltimore, Md. : 1950), 2021
"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.
Uppala R et al.
Cellular & Molecular Immunology, 2021
UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex.
Mazzone P et al.
International Journal of Molecular Sciences, 2020
Regulation and dysregulation of CARD14 signalling and its physiological consequences in inflammatory skin disease.
Mellett M
Cellular Immunology, 2020
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
Van Nuffel E et al.
Embo Reports, 2020
Two cases of CARD14-associated papulosquamous eruption from India.
Chiramel MJ et al.
Pediatric Dermatology, 2020
CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.
Manils J et al.
Elife, 2020
CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.
Voccola S et al.
Journal of Cellular Physiology, 2020
Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity.
Sundberg JP et al.
Experimental and Molecular Pathology, 2019
Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients.
Gunter NV et al.
Frontiers in Genetics, 2019
Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort.
Zhang Z et al.
The Journal of Investigative Dermatology. Symposium Proceedings, 2018
CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo.
Mellett M et al.
The Journal of Investigative Dermatology, 2018
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
Wang M et al.
Immunity, 2018
Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.
Akiyama M et al.
Journal of Dermatological Science, 2018
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Juilland M et al.
Frontiers in Immunology, 2018
CARD14/CARMA2 Signaling and its Role in Inflammatory Skin Disorders.
Zotti T et al.
Frontiers in Immunology, 2018
Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin Disease.
Israel L et al.
Frontiers in Immunology, 2018
The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling.
Telesio G et al.
International Journal of Molecular Sciences, 2017
CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.
Van Nuffel E et al.
The Journal of Investigative Dermatology, 2017
CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.
Scudiero I et al.
Cell Death & Disease, 2017
Monogenic Autoinflammatory Diseases with Mendelian Inheritance: Genes, Mutations, and Genotype/Phenotype Correlations.
Martorana D et al.
Frontiers in Immunology, 2017
Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.
Howes A et al.
The Biochemical Journal, 2016
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.
Afonina IS et al.
Embo Reports, 2016
One SNP at a Time: Moving beyond GWAS in Psoriasis.
Ray-Jones H et al.
The Journal of Investigative Dermatology, 2016
Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai-Tibetan Plateau.
Chen Y et al.
Blood Cells, Molecules & Diseases, 2016
CARD14 Glu138 mutation in familial pityriasis rubra pilaris does not warrant differentiation from familial psoriasis.
Inoue N et al.
The Journal of Dermatology, 2016
CARD14 alterations in Tunisian patients with psoriasis and further characterization in European cohorts.
Ammar M et al.
The British Journal of Dermatology, 2016
Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.
Berki DM et al.
The Journal of Investigative Dermatology, 2015
Functional characterization of zebrafish (Danio rerio) Bcl10.
Mazzone P et al.
Plos One, 2015