Associated Papers
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo.
Reinke S et al.
Cell Reports, 2020
CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.
Kapplusch F et al.
Clinical Immunology (orlando, Fla.), 2019
Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease.
Luksch H et al.
Current Rheumatology Reports, 2015
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.
Heymann MC et al.
Journal of Immunology (baltimore, Md. : 1950), 2014
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.
Luksch H et al.
Human Mutation, 2013
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