Associated Papers
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.
Zhou B et al.
Cell Reports, 2021
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo.
Reinke S et al.
Cell Reports, 2020
CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.
Kapplusch F et al.
Clinical Immunology (orlando, Fla.), 2019
ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
Lee BL et al.
Scientific Reports, 2018
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.
Eldridge MJG et al.
Cell Reports, 2017
28147281 (PubMed )
Supplement: mmc1.pdf
Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division.
Stein R et al.
The Journal of Biological Chemistry, 2016
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
He WT et al.
Cell Research, 2015
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.
Cai X et al.
Cell, 2014
Proteolytic processing of Nlrp1b is required for inflammasome activity.
Frew BC et al.
Plos Pathogens, 2012
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.
Kofoed EM et al.
Nature, 2011
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