Varaico: Literature-Extracted Genetic Variants

Gene:CASP8
Variant:p.Y380F
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CASP8

NM_001372051.1:p.Y380F

Associated Papers

Caspase-8 expression and its Src dependent phosphorylation on Tyrosine 380 triggers NRF2 signaling activation in glioblastoma.

Cirotti C et al.

Cell Death and Differentiation, 2025

Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.

Powley IR et al.

Oncogene, 2016

Critical role for caspase-8 in epidermal growth factor signaling.

Finlay D et al.

Cancer Research, 2009

Caspase 8 promotes peripheral localization and activation of Rab5.

Torres VA et al.

The Journal of Biological Chemistry, 2008

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.

Barbero S et al.

The Journal of Biological Chemistry, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."