Varaico: Literature-Extracted Genetic Variants

Gene:CASR
Variant:p.T145A
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CASR

NM_000388.4:p.T145A

Associated Papers

Structural Mechanism of Cooperative Regulation of Calcium-Sensing Receptor-Mediated Cellular Signaling.

Deng X et al.

Current Opinion in Physiology, 2020

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.

Leach K et al.

Pharmacological Reviews, 2020

Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor.

Zhang C et al.

Frontiers in Physiology, 2016

The calcium sensing receptor: from calcium sensing to signaling.

Zhang C et al.

Science China. Life Sciences, 2015

Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

Zhang C et al.

The Journal of Biological Chemistry, 2014

The CASR gene: alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: structure and ligand binding sites.

Hendy GN et al.

Best Practice & Research. Clinical Endocrinology & Metabolism, 2013

Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways.

Conigrave AD et al.

Best Practice & Research. Clinical Endocrinology & Metabolism, 2013

Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

Broadhead GK et al.

The Journal of Biological Chemistry, 2011

Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.

Jiang Y et al.

The Journal of Biological Chemistry, 2010

Molecular basis for amino acid sensing by family C G-protein-coupled receptors.

Wellendorph P et al.

British Journal of Pharmacology, 2009

Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.

Huang Y et al.

The Journal of Biological Chemistry, 2007

A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.

Mun HC et al.

The Journal of Biological Chemistry, 2005

[The functions of calcium-sensing receptor in regulating mineral metabolism.]

Kinoshita Y

Clinical Calcium, 0

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