Varaico: Literature-Extracted Genetic Variants

Gene:CASR
Variant:p.S169A
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CASR

NM_000388.4:p.S169A

Associated Papers

Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

Zhang C et al.

The Journal of Biological Chemistry, 2014

Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.

Zhang C et al.

Plos One, 2014

Molecular basis for amino acid sensing by family C G-protein-coupled receptors.

Wellendorph P et al.

British Journal of Pharmacology, 2009

A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.

Mun HC et al.

The Journal of Biological Chemistry, 2005

Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function.

Zhang Z et al.

The Journal of Biological Chemistry, 2002

The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.

Bräuner-Osborne H et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."