Associated Papers
Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.
Binmahfouz LS et al.
Molecular Pharmacology, 2025
Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor.
Matarage Don NNJ et al.
Acs Chemical Biology, 2024
Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges.
Ma S et al.
Communications Biology, 2024
Upacicalcet Is a Novel Secondary Hyperparathyroidism Drug that Targets the Amino Acid Binding Site of Calcium-Sensing Receptor .
Sato H et al.
Molecular Pharmacology, 2022
Structural insights into the activation of human calcium-sensing receptor.
Chen X et al.
Elife, 2021
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan.
Ling S et al.
Cell Research, 2021
Calcium-Sensing Receptor Internalization Is β-Arrestin-Dependent and Modulated by Allosteric Ligands.
Mos I et al.
Molecular Pharmacology, 2019
Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.
Jacobsen SE et al.
Scientific Reports, 2017
Structural mechanism of ligand activation in human calcium-sensing receptor.
Geng Y et al.
Elife, 2016
GENETICS IN ENDOCRINOLOGY: Gain and loss of function mutations of the calcium-sensing receptor and associated proteins: current treatment concepts.
Mayr B et al.
European Journal of Endocrinology, 2016
Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.
Zhang C et al.
Plos One, 2014
Molecular basis for amino acid sensing by family C G-protein-coupled receptors.
Wellendorph P et al.
British Journal of Pharmacology, 2009
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.
Huang Y et al.
The Journal of Biological Chemistry, 2007
Inherited endocrine diseases involving G proteins and G protein-coupled receptors.
Spiegel AM
Endocrine Development, 2007
Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor.
Silve C et al.
The Journal of Biological Chemistry, 2005
A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.
Mun HC et al.
The Journal of Biological Chemistry, 2005
Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function.
Zhang Z et al.
The Journal of Biological Chemistry, 2002
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.
Bräuner-Osborne H et al.
The Journal of Biological Chemistry, 1999