Associated Papers
Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor.
Matarage Don NNJ et al.
Acs Chemical Biology, 2024
Upacicalcet Is a Novel Secondary Hyperparathyroidism Drug that Targets the Amino Acid Binding Site of Calcium-Sensing Receptor .
Sato H et al.
Molecular Pharmacology, 2022
Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca2+ Sensing but Not G Protein Interaction.
Goolam MA et al.
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 2022
Asymmetric activation of the calcium-sensing receptor homodimer.
Gao Y et al.
Nature, 2021
Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Wen T et al.
Science Advances, 2021
Calcium-Sensing Receptor Internalization Is β-Arrestin-Dependent and Modulated by Allosteric Ligands.
Mos I et al.
Molecular Pharmacology, 2019
Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.
Jacobsen SE et al.
Scientific Reports, 2017
GENETICS IN ENDOCRINOLOGY: Gain and loss of function mutations of the calcium-sensing receptor and associated proteins: current treatment concepts.
Mayr B et al.
European Journal of Endocrinology, 2016
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.
Leach K et al.
Cell Research, 2016
The calcium sensing receptor: from calcium sensing to signaling.
Zhang C et al.
Science China. Life Sciences, 2015
Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
Ma JN et al.
The Journal of Pharmacology and Experimental Therapeutics, 2011
Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one.
Fukuda J et al.
Neuropharmacology, 2009
Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants.
Al-Fulaij MA et al.
Journal of Molecular Neuroscience : Mn, 2008
A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.
Hu J et al.
The Journal of Biological Chemistry, 2006
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.
Hu J et al.
The Journal of Biological Chemistry, 2005
The role of cysteines and charged amino acids in extracellular loops of the human Ca(2+) receptor in cell surface expression and receptor activation processes.
Ray K et al.
Endocrinology, 2004
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.
Petrel C et al.
The Journal of Biological Chemistry, 2004
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.
Petrel C et al.
The Journal of Biological Chemistry, 2003
Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator.
Hu J et al.
The Journal of Biological Chemistry, 2002
Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.
Hu J et al.
Journal of Cellular and Molecular Medicine, 0