Associated Papers
CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity.
Liu C et al.
Molecular Cell, 2026
Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex.
Jansen RM et al.
Nature Structural & Molecular Biology, 2025
Structural basis for the dynamic regulation of mTORC1 by amino acids.
Valenstein ML et al.
Nature, 2025
Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex.
Su MY et al.
Cell Reports, 2025
Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex.
Jansen RM et al.
Research Square, 2025
New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing.
Yang C et al.
Bioscience Reports, 2024
Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states.
Zhou Y et al.
Biochemical and Biophysical Research Communications, 2019
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Saxton RA et al.
Nature, 2016
Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.
Gai Z et al.
Cell Discovery, 2016
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