Associated Papers
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Ahmed SF et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2025
CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration.
Song H et al.
Journal of Cachexia, Sarcopenia and Muscle, 2024
CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.
Belizaire R et al.
Blood, 2021
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
Ahmed SF et al.
Oncogene, 2021
Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.
Wybenga-Groot LE et al.
Acta Crystallographica. Section F, Structural Biology Communications, 2021
E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation.
Shen J et al.
Frontiers in Cell and Developmental Biology, 2021
C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6.
Jang HD et al.
Cellular & Molecular Biology Letters, 2019
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Hyrenius-Wittsten A et al.
Nature Communications, 2018
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
Nadeau SA et al.
The Journal of Biological Chemistry, 2017
c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors.
Shashar M et al.
Oncotarget, 2016
The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy.
Yang N et al.
Biochemical and Biophysical Research Communications, 2016
Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.
Polzer H et al.
Experimental Hematology, 2013
E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.
Sévère N et al.
Cell Death & Disease, 2013
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.
Mohapatra B et al.
Biochimica Et Biophysica Acta, 2013
EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.
Dutta D et al.
Plos Pathogens, 2013
Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.
Nadeau S et al.
Biochemistry and Analytical Biochemistry : Current Research, 2012
c-Cbl regulates glioma invasion through matrix metalloproteinase 2.
Lee H et al.
Journal of Cellular Biochemistry, 2010
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Ogawa S et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2010
c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest.
Shen M et al.
The Journal of Biological Chemistry, 2009
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Ng C et al.
The Embo Journal, 2008
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
Fasen K et al.
Traffic (copenhagen, Denmark), 2008
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.
Sanjay A et al.
The Febs Journal, 2006
Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.
Lane HC et al.
International Immunology, 2006
The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules.
Teckchandani AM et al.
Experimental Cell Research, 2005
Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.
Kaabeche K et al.
Journal of Cell Science, 2005
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.
Moon KD et al.
The Journal of Biological Chemistry, 2005
Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment.
de Melker AA et al.
The Journal of Biological Chemistry, 2004
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.
Kaabeche K et al.
The Journal of Biological Chemistry, 2004
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.
Kassenbrock CK et al.
The Journal of Biological Chemistry, 2004
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
Thien CB et al.
The Journal of Experimental Medicine, 2003
The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.
Scaife RM et al.
Journal of Cell Science, 2003
An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.
Rao N et al.
Signal Transduction, 2002
Negative regulation of EphA2 receptor by Cbl.
Wang Yj et al.
Biochemical and Biophysical Research Communications, 2002
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.
Freywald A et al.
The Journal of Biological Chemistry, 2002
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
Waterman H et al.
The Embo Journal, 2002
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.
Peschard P et al.
Molecular Cell, 2001
Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.
Yokouchi M et al.
The Journal of Biological Chemistry, 2001
The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells.
Rao N et al.
Journal of Immunology (baltimore, Md. : 1950), 2000
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression.
Rosenkranz S et al.
The Journal of Biological Chemistry, 2000
The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.
Ota S et al.
The Journal of Biological Chemistry, 2000
c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology.
Scaife RM et al.
Journal of Cell Science, 2000
Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain.
Yankee TM et al.
Journal of Immunology (baltimore, Md. : 1950), 1999
Enhancement of fcgamma receptor-mediated phagocytosis by transforming mutants of Cbl.
Sato N et al.
Journal of Immunology (baltimore, Md. : 1950), 1999
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.
Yokouchi M et al.
The Journal of Biological Chemistry, 1999
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.
Miyake S et al.
The Journal of Biological Chemistry, 1999
The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases.
Broome MA et al.
Oncogene, 1999
Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association.
van Leeuwen JE et al.
The Journal of Biological Chemistry, 1999
Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.
Lupher ML et al.
The Journal of Biological Chemistry, 1998
c-Cbl: a regulator of T cell receptor-mediated signalling.
Thien CB et al.
Immunology and Cell Biology, 1998