Varaico: Literature-Extracted Genetic Variants

Gene:CCAR2
Variant:p.T454A
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CCAR2

NM_001393997.1:p.T454A

Associated Papers

CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining.

Iyer DR et al.

Proceedings of the National Academy of Sciences of the United States of America, 2022

36442094 (PubMed )
Supplement: pnas.2214935119.sapp.pdf

A novel assay for screening WIP1 phosphatase substrates in nuclear extracts.

Storchova R et al.

The Febs Journal, 2021

Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions.

Lee J et al.

Molecules and Cells, 2015

CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage.

Magni M et al.

Oncotarget, 2015

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.

Magni M et al.

Nucleic Acids Research, 2014

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

Zannini L et al.

Journal of Molecular Cell Biology, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."